(+)-(5R)-methyl-4-oxo-octane-1,8-dioic acid, microbiological degradation product from rings C and D of cholic acid
نویسندگان
چکیده
منابع مشابه
Microbiological degradation of bile acids. Nitrogenous hexahydroindane derivatives formed from cholic acid by Streptomyces rubescens.
The metabolism of cholic acid (I) by Streptomyces rubescens was investigated. This organism effected ring A cleavage, side-chain shortening and amide bond formation and gave the following metabolites: (4R)-4-[4alpha-(2-carboxyethyl)-3aalpha-hexahydro-7abeta-methyl-5-oxoindan-1 beta-yl]valeric acid (IIa) and its mono-amide (valeramide) (IIb); and 2,3,4,6, 6abeta,7,8,9,9aalpha,9bbeta-decahydro-6a...
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In the title compound, C(18)H(16)N(2)O(3), a potential inhibitor of the cyclo-oxygenase-2 isoenzyme, the pyrazoline ring exists in a flattened envelope conformation with one C atom deviating by 0.463 Å from the mean plane of the remaining four atoms. The puckering of the central oxazine ring is more severe, with one N atom and one C atom displaced by 0.235 (6) and 0.370 (2) Å, respectively, on ...
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acid also increases on storage it is not-yet possible to say in which form the vitamin is primarily synthesized. The nature of the changes underlying the phenomenon is still obscure. The evidence strongly suggests, but does not absolutely prove, that the vitamin is formed from a chemically related precuesor during storage. The increase of vitamin C in an apple of about 22 g. during 7 months of ...
متن کامل3-(4-Methoxyphenyl)pent-2-ene-1,5-dioic acid
In the title compound, C(12)H(12)O(5), mol-ecules are linked into anti-parallel hydrogen-bonded sheets through inversion dimers generated via two O-H⋯O hydrogen bonds. Using the R(2) (2)(8) motif as a building block, hydrogen-bonded chains of a C(2) (2)(8) superstructure are then generated.
متن کاملThe degradation of cholic acid by Pseudomonas sp. N.C.I.B. 10590.
The microbial degradation of cholic acid by Pseudomonas sp. N.C.I.B. 10590 was studied, and two major products were isolated and identified as 7 alpha, 12 beta-dihydroxyandrosta-1,4-diene-3,17-dione and 7 alpha, 12 alpha-dihydroxy-3-oxopregna-1,4-diene-20-carboxylic acid. Four minor products were isolated and evidence is given for the following structures: 7 alpha, 12 alpha-dihydroxyandrosta-1,...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1969
ISSN: 0306-3283
DOI: 10.1042/bj1120127